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Gilbert’s syndrome

Definition:
A multifactorial inherited disorder that affects the way bilirubin is processed by the liver and causes jaundice.
Alternative Names:
Icterus intermittens juvenilis; Low-grade chronic hyperbilirubinemia; Familial non-hemolytic – non-obstructive jaundice; Constitutional liver dysfunction; Unconjugated benign bilirubinemia
Causes, incidence, and risk factors:
Gilbert’s disease is common, affecting up to 10% of some Caucasian populations. The most significant symptom of this condition is jaundice. Affected individuals usually have no jaundice. However, jaundice appears under conditions of exertion, stress, fasting, and infections. The condition is usually benign.
Review Date: 12/3/2001
Reviewed By: Andrew J. Muir, M.D. M.H.S., Division of Gastroenterology, Duke University Medical Center, Durham, NC. Review provided by VeriMed Healthcare Network.
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